IFITM1 anticorps (N-Term)

N° du produit ABIN3044336

L’anticorps Lapin Polyclonal anti-IFITM1 a été validé pour WB et IHC. Il convient pour détecter IFITM1 dans des échantillons de Humain. Il y a 3+ publications disponibles.

Aperçu rapide pour IFITM1 anticorps (N-Term) (ABIN3044336)

Antigène: IFITM1 (Interferon-Induced Transmembrane Protein 1 (IFITM1))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp IFITM1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Détail du produit anti-IFITM1 anticorps

Épitope: AA 1-17, N-Term

Fonction: Anti-IFITM1 Antibody Picoband®

Séquence: MHKEEHEVAV LGPPPST

Réactivité croisée (Details): No cross-reactivity with other proteins

Attributs du produit: Anti-IFITM1 Antibody (ABIN3044336). Tested in IHC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Purification: Immunogen affinity purified.

Immunogène: A synthetic peptide corresponding to a sequence at the N-terminus of human IFITM1.

Isotype: IgG

Information d'application

Indications d'application: Immunohistochemistry (Frozen Section), 0.5-1 μg/mL, Human, -
Immunohistochemistry (Paraffin-embedded Section), 0.5-1 μg/mL, Human
Western blot, 0.1-0.5 μg/mL, Human
1. Tanaka, S. S., Yamaguchi, Y. L., Tsoi, B., Lickert, H., Tam, P. P. L. : IFITM/Mil/Fragilis family proteins IFITM1 and IFITM3 play distinct roles in mouse primordial germ cell homing and repulsion. Dev. Cell 9: 745-756, 2005. 2. Deblandre, G. A., Marinx, O. P., Evans. S. S., Majjaj, S., Leo, O., Caput, D., Huez, G. A., Wathelet, M. G. : Expression cloning of an interferon-inducible 17- kDa membrane protein implicated in the control of cell growth. J. Biol. Chem. 270: 23860-23866, 1995.

Commentaires:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P) and IHC(F).

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.

Agent conservateur: Thimerosal (Merthiolate), Sodium azide

Précaution d'utilisation: This product contains Thimerosal (Merthiolate) and Sodium azide: POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Références pour anticorps anti-IFITM1 (ABIN3044336)

Ma, Zhang, Fu, Xia, Zhan, Li, Wang, Wu: "Wnt signaling may be activated in a subset of Peutz-Jeghers syndrome polyps closely correlating to LKB1 expression." dans: Oncology reports, Vol. 23, Issue 6, pp. 1569-76, (2010) (PubMed).

Xu, Yang, Hu: "Binding of IFITM1 enhances the inhibiting effect of caveolin-1 on ERK activation." dans: Acta biochimica et biophysica Sinica, Vol. 41, Issue 6, pp. 488-94, (2009) (PubMed).

Yang, Xu, Chen, Hu: "IFITM1 plays an essential role in the antiproliferative action of interferon-gamma." dans: Oncogene, Vol. 26, Issue 4, pp. 594-603, (2007) (PubMed).

Détails sur IFITM1

Antigène: IFITM1 (Interferon-Induced Transmembrane Protein 1 (IFITM1))

Autre désignation: IFITM1

Sujet:

Synonyms: Interferon-induced transmembrane protein 1,Dispanin subfamily A member 2a,DSPA2a,Interferon-induced protein 17,Interferon-inducible protein 9-27,Leu-13 antigen,CD225,IFITM1,CD225, IFI17,

Tissue Specificity: Bone (at protein level). Levels greatly elevated in colon cancer, cervical cancer, esophageal cancer and ovarian cancer. Expressed in glioma cell lines. .

Background: Interferon-induced Transmembrane Protein 1 (IFITM1), also called Interferon-induced Protein 17 (IFI17). IFITM1 activity is required for primordial germ cells (PGCs) transit from the mesoderm into the endoderm, and that it appears to act via a repulsive mechanism, such that PGCs avoid Ifitm1-expressing tissues. It is mapped to Chr.11 and belongs to the family of interferon-induced transmembrane proteins (Ifitm/mil/fragilis), which encodes cell surface proteins that may modulate cell adhesion and influence cell differentiation. Interferon-inducible membrane proteins of approximately 17 kDa have been suggested to play a role in the antiproliferative activity of interferons based on their pattern of induction in interferon-sensitive and -resistant cell lines and the ability of a membrane fraction enriched in 17- kDa proteins to inhibit cell growth.

Sequence Similarities: Belongs to the intermediate filament family.

Poids moléculaire: 70-74 kDa

UniProt: P13164